{"id":620,"date":"2022-06-28T14:46:28","date_gmt":"2022-06-28T17:46:28","guid":{"rendered":"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/?p=620"},"modified":"2022-06-28T14:46:28","modified_gmt":"2022-06-28T17:46:28","slug":"estrategias-para-melhorar-a-performance-2","status":"publish","type":"post","link":"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/estrategias-para-melhorar-a-performance-2\/","title":{"rendered":"Estrat\u00e9gias para melhorar a performance"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">O que todos n\u00f3s procuramos \u00e9 melhorar nossa performance nas atividades em que exercemos para alcan\u00e7armos de forma mais r\u00e1pida e eficiente os objetivos esperados. O exerc\u00edcio f\u00edsico com uma alimenta\u00e7\u00e3o e nutri\u00e7\u00e3o adequada s\u00e3o essenciais para a conquista dos resultados. A suplementa\u00e7\u00e3o com ativos que s\u00e3o capazes de melhorar a execu\u00e7\u00e3o dessas atividades e auxiliar nossa recupera\u00e7\u00e3o \u00e9 uma boa estrat\u00e9gia para alcan\u00e7ar tais objetivos e nos estimular cada vez mais a tra\u00e7ar novas metas.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Beta-alanina e carnosina.\u00a0<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">A carnosina \u00e9 uma subst\u00e2ncia produzida naturalmente no corpo a partir dos precursores beta-alanina e histidina. \u00c9 altamente concentrado no tecido cerebral e nos m\u00fasculos. Embora seja bem conhecida por seus efeitos anti-glica\u00e7\u00e3o, evid\u00eancias acumuladas sugerem que a carnosina desempenha pap\u00e9is importantes no desempenho do exerc\u00edcio e na sa\u00fade do m\u00fasculo esquel\u00e9tico. O componente carnosina beta-alanina tamb\u00e9m exibe propriedades ergog\u00eanicas. Como \u00e9 um precursor da carnosina, v\u00e1rios estudos usaram a suplementa\u00e7\u00e3o de beta-alanina para aumentar os n\u00edveis de carnosina e melhorar o desempenho nos exerc\u00edcios.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A carnosina protege os m\u00fasculos do estresse oxidativo relacionado ao exerc\u00edcio e impede o ac\u00famulo de \u00e1cido l\u00e1tico para reduzir a fadiga muscular. 270 Um estudo cl\u00ednico em 14 atletas do sexo masculino descobriu que a suplementa\u00e7\u00e3o com 4 gramas de carnosina por dia durante 14 dias levou a uma atenua\u00e7\u00e3o significativa na perda de glutationa induzida pelo exerc\u00edcio, ao mesmo tempo que reduziu os marcadores de estresse oxidativo.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Uma meta-an\u00e1lise de 40 estudos individuais compreendendo 1.461 participantes identificou um efeito geral positivo significativo da suplementa\u00e7\u00e3o de beta-alanina (variando de 2 a 6,4 gramas por dia durante 4-12 semanas), apoiando a efic\u00e1cia do aumento da carnosina muscular no desempenho e capacidade de exerc\u00edcio melhorados. Um ensaio randomizado controlado por placebo examinando 23 judocas altamente treinadas descobriu que participantes que consumiram 6,4 gramas de beta-alanina por dia mostraram uma melhora significativa na resist\u00eancia ao exerc\u00edcio em quatro semanas. Em outro ensaio cl\u00ednico controlado, 30 indiv\u00edduos saud\u00e1veis \u200b\u200bcom treinamento de for\u00e7a receberam placebo ou 6,4 gramas de beta-alanina por dia durante cinco semanas, ap\u00f3s o que o grupo de beta-alanina mostrou melhorias significativas na for\u00e7a m\u00e1xima e produ\u00e7\u00e3o de energia. Um estudo que envolveu 12 participantes saud\u00e1veis \u200b\u200bdescobriu que a suplementa\u00e7\u00e3o com 2 gramas de carnosina mais 2 gramas de beta-alanina quatro horas antes dos testes de exerc\u00edcio melhorou algumas medidas de desempenho muscular e resist\u00eancia.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Em dois estudos cruzados, duplo-cegos, controlados por placebo, a suplementa\u00e7\u00e3o com 20 mg\/kg de peso corporal de carnosina mais anserina, uma vers\u00e3o metilada de carnosina com meia-vida melhorada, levou a uma pot\u00eancia significativamente maior em um teste de aptid\u00e3o padronizado ap\u00f3s 6 minutos de ciclismo de alta intensidade. Em outro ensaio cl\u00ednico randomizado de 50 pacientes com insufici\u00eancia card\u00edaca cr\u00f4nica est\u00e1vel e disfun\u00e7\u00e3o sist\u00f3lica ventricular esquerda grave, j\u00e1 em terapia m\u00e9dica ideal, 500 mg de carnosina por dia na forma de pastilha por seis meses levaram a uma melhora na dist\u00e2ncia de caminhada na caminhada de 6 minutos teste e aumento da capacidade aer\u00f3bia durante o exerc\u00edcio.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">No geral, muitos estudos mostraram efeitos positivos da suplementa\u00e7\u00e3o com carnosina e\/ou beta-alanina para exerc\u00edcio e desempenho esportivo. No entanto, a literatura n\u00e3o \u00e9 totalmente consistente. V\u00e1rios estudos relataram pouco ou nenhum efeito da suplementa\u00e7\u00e3o de beta-alanina nas medidas de desempenho nos exerc\u00edcios. Alguns autores sugeriram que a variabilidade dos efeitos observados pode ser devido \u00e0s demandas fisiol\u00f3gicas vari\u00e1veis \u200b\u200bde diferentes atividades esportivas ou caracter\u00edsticas basais dos participantes do estudo, como nutri\u00e7\u00e3o geral, grau de condicionamento f\u00edsico e h\u00e1bitos de sono. Mais estudos com grandes tamanhos de amostra e metodologias rigorosas s\u00e3o necess\u00e1rios para esclarecer a efic\u00e1cia da suplementa\u00e7\u00e3o de carnosina e\/ou beta-alanina no desempenho do exerc\u00edcio.<\/span><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Suporte adicional<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">D-ribose\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A D-ribose \u00e9 a forma biologicamente ativa do a\u00e7\u00facar que ocorre naturalmente, a ribose, e \u00e9 produzida no corpo a partir da glicose. A ribose est\u00e1 envolvida na s\u00edntese de ATP, que fornece energia \u00e0s c\u00e9lulas musculares durante o exerc\u00edcio. A suplementa\u00e7\u00e3o com ribose acelerou a s\u00edntese de ATP ap\u00f3s seu esgotamento durante o exerc\u00edcio intenso.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Um ensaio controlado com 12 fisiculturistas masculinos recreativos descobriu que a suplementa\u00e7\u00e3o com 10 gramas de ribose por dia durante quatro semanas resultou em maiores ganhos de for\u00e7a muscular e resist\u00eancia do que o placebo. A D-ribose tamb\u00e9m pode ajudar a combater a fadiga e melhorar o humor e a vitalidade em adultos idosos, o que pode permitir o aumento da frequ\u00eancia de exerc\u00edcios. Um estudo de dosagem descobriu que tomar D-ribose com o est\u00f4mago vazio leva a uma absor\u00e7\u00e3o mais eficiente do que tom\u00e1-lo com alimentos.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Periodicamente, surgem preocupa\u00e7\u00f5es em rela\u00e7\u00e3o ao potencial da D-ribose em promover rea\u00e7\u00f5es de glica\u00e7\u00e3o prejudiciais. Embora a ribose possa contribuir para as rea\u00e7\u00f5es de glica\u00e7\u00e3o quando presente em altas concentra\u00e7\u00f5es, a quantidade de D-ribose obtida com a suplementa\u00e7\u00e3o n\u00e3o \u00e9 preocupante. Essas preocupa\u00e7\u00f5es foram abordadas exaustivamente em um artigo intitulado \u201c<\/span><i><span style=\"font-weight: 400;\">Restoring Cellular Energy Metabolism\u201d<\/span><\/i><span style=\"font-weight: 400;\"> na edi\u00e7\u00e3o de outubro de 2012 da Life Extension Magazine.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">\u00d4mega-3<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Um crescente corpo de evid\u00eancias ap\u00f3ia o uso de gorduras \u00f4mega-3 para melhorar a recupera\u00e7\u00e3o de exerc\u00edcios extenuantes. Os \u00e1cidos graxos \u00f4mega-3, particularmente o \u00e1cido eicosapentaen\u00f3ico (EPA), podem ser ben\u00e9ficos na preven\u00e7\u00e3o e no tratamento da sarcopenia. Em um estudo controlado em adultos mais velhos, a suplementa\u00e7\u00e3o di\u00e1ria com \u00e1cidos graxos \u00f4mega-3 contendo mais de 1,8 gramas de EPA e 1,5 gramas de \u00e1cido docosahexaen\u00f3ico (DHA) aumentou a taxa de s\u00edntese de prote\u00edna muscular em compara\u00e7\u00e3o com um \u00f3leo de milho, que n\u00e3o trouxe nenhum benef\u00edcio.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">Coenzima Q10<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A coenzima Q10 (CoQ10) \u00e9 um componente essencial da s\u00e9rie de rea\u00e7\u00f5es bioqu\u00edmicas que geram energia nas mitoc\u00f4ndrias da c\u00e9lula. CoQ10 tamb\u00e9m funciona como um eliminador de radicais livres, protegendo as c\u00e9lulas contra danos oxidativos. Estudos cl\u00ednicos demonstraram um efeito de aumento do exerc\u00edcio da suplementa\u00e7\u00e3o com CoQ10. Em um estudo com indiv\u00edduos treinados e n\u00e3o treinados, a suplementa\u00e7\u00e3o com 100 mg de CoQ10 por 14 dias aumentou o tempo que os participantes podiam se exercitar antes de chegar \u00e0 exaust\u00e3o.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Um estudo randomizado controlado em corredores masculinos descobriu que 14 dias de suplementa\u00e7\u00e3o com CoQ10 reduziu o aumento nos n\u00edveis sangu\u00edneos de lactato, interleucina-6, fator de necrose tumoral alfa e prote\u00edna C reativa induzida por uma sess\u00e3o de corrida competitiva de meia dist\u00e2ncia. A dose de CoQ10 usada no estudo foi de 5 mg\/kg\/dia, ou cerca de 350 mg por dia para uma pessoa de 70kg.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Em um estudo com animais, ratos foram suplementados com CoQ10 por seis semanas durante o treinamento de exerc\u00edcio. Isso produziu mudan\u00e7as ben\u00e9ficas nos n\u00edveis das prote\u00ednas regulat\u00f3rias principais, incluindo o fator nuclear kappaB e Nrf2, ambos os quais defendem contra a inflama\u00e7\u00e3o e o estresse oxidativo.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">Arginina<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A arginina \u00e9 um amino\u00e1cido condicionalmente essencial que participa de uma variedade de vias metab\u00f3licas, incluindo a s\u00edntese de prote\u00ednas. \u00c9 importante ressaltar que a arginina \u00e9 um precursor do \u00f3xido n\u00edtrico (NO), um potente vasodilatador. A suplementa\u00e7\u00e3o de arginina pode aumentar o fluxo sangu\u00edneo para os m\u00fasculos.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Em um ensaio cl\u00ednico controlado em ciclistas competitivos do sexo masculino, a suplementa\u00e7\u00e3o com 6 gramas de L-arginina diariamente por tr\u00eas dias aumentou o desempenho de 20 quil\u00f4metros no contra-rel\u00f3gio, reduziu o consumo de oxig\u00eanio e reduziu a press\u00e3o arterial sist\u00f3lica e diast\u00f3lica. Em outro ensaio cl\u00ednico controlado em homens n\u00e3o treinados em idade universit\u00e1ria, a suplementa\u00e7\u00e3o com um produto contendo 1,5 gramas ou 3 gramas de arginina (junto com extrato de semente de uva) por quatro semanas reduziu o tempo para o in\u00edcio da fadiga induzida por ciclismo em compara\u00e7\u00e3o com o placebo.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Estudos em animais indicam que a suplementa\u00e7\u00e3o de arginina pode ser ben\u00e9fica para a recupera\u00e7\u00e3o do exerc\u00edcio. Esses efeitos foram atribu\u00eddos ao aumento do conte\u00fado de \u00f3xido n\u00edtrico nos m\u00fasculos.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">Refer\u00eancias<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Life Extension. Dispon\u00edvel em: &lt;https:\/\/www.lifeextension.com\/protocols\/lifestyle-longevity\/exercise&gt;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. <\/span><i><span style=\"font-weight: 400;\">J Clin Pharmacol. <\/span><\/i><span style=\"font-weight: 400;\">May 2014;54(5):546-554.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Corder KE, Newsham KR, McDaniel JL, Ezekiel UR, Weiss EP. Effects of Short-Term Docosahexaenoic Acid Supplementation on Markers of Inflammation after Eccentric Strength Exercise in Women. <\/span><i><span style=\"font-weight: 400;\">J Sports Sci Med. <\/span><\/i><span style=\"font-weight: 400;\">Mar 2016;15(1):176-183.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Jouris KB, McDaniel JL, Weiss EP. The Effect of Omega-3 Fatty Acid Supplementation on the Inflammatory Response to eccentric strength exercise. <\/span><i><span style=\"font-weight: 400;\">J Sports Sci Med. <\/span><\/i><span style=\"font-weight: 400;\">2011;10(3):432-438.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Jeromson S, Gallagher IJ, Galloway SD, Hamilton DL. Omega-3 Fatty Acids and Skeletal Muscle Health. <\/span><i><span style=\"font-weight: 400;\">Mar Drugs. <\/span><\/i><span style=\"font-weight: 400;\">Nov 2015;13(11):6977-7004.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer B. Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial. <\/span><i><span style=\"font-weight: 400;\">The American journal of clinical nutrition. <\/span><\/i><span style=\"font-weight: 400;\">Feb 2011;93(2):402-412.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sarmiento A, Diaz-Castro J, Pulido-Moran M, Kajarabille N, Guisado R, Ochoa JJ. Coenzyme Q10 Supplementation and Exercise in Healthy Humans: A Systematic Review. <\/span><i><span style=\"font-weight: 400;\">Current drug metabolism. <\/span><\/i><span style=\"font-weight: 400;\">2016;17(4):345-358.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Pala R, Orhan C, Tuzcu M, Sahin N, Ali S, Cinar V, . . . Sahin K. Coenzyme Q10 Supplementation Modulates NFkappaB and Nrf2 Pathways in Exercise Training. <\/span><i><span style=\"font-weight: 400;\">J Sports Sci Med. <\/span><\/i><span style=\"font-weight: 400;\">Mar 2016;15(1):196-203.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Kumar A, Kaur H, Devi P, Mohan V. Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome. <\/span><i><span style=\"font-weight: 400;\">Pharmacology &amp; therapeutics. <\/span><\/i><span style=\"font-weight: 400;\">Dec 2009;124(3):259-268.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Gokbel H, Gul I, Belviranl M, Okudan N. The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men. <\/span><i><span style=\"font-weight: 400;\">Journal of strength and conditioning research \/ National Strength &amp; Conditioning Association. <\/span><\/i><span style=\"font-weight: 400;\">Jan 2010;24(1):97-102.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Cooke M, Iosia M, Buford T, Shelmadine B, Hudson G, Kerksick C, . . . Kreider R. Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. <\/span><i><span style=\"font-weight: 400;\">Journal of the International Society of Sports Nutrition. <\/span><\/i><span style=\"font-weight: 400;\">2008;5:8.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Armanfar M, Jafari A, Dehghan GR, Abdizadeh L. Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners. <\/span><i><span style=\"font-weight: 400;\">Medical journal of the Islamic Republic of Iran. <\/span><\/i><span style=\"font-weight: 400;\">2015;29:202.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Camic CL, Housh TJ, Zuniga JM, Hendrix RC, Mielke M, Johnson GO, Schmidt RJ. Effects of arginine-based supplements on the physical working capacity at the fatigue threshold. <\/span><i><span style=\"font-weight: 400;\">Journal of strength and conditioning research \/ National Strength &amp; Conditioning Association. <\/span><\/i><span style=\"font-weight: 400;\">May 2010;24(5):1306-1312.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Campbell BI, La Bounty PM, Roberts M. The ergogenic potential of arginine. <\/span><i><span style=\"font-weight: 400;\">Journal of the International Society of Sports Nutrition. <\/span><\/i><span style=\"font-weight: 400;\">2004;1(2):35-38.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">McConell GK. Effects of L-arginine supplementation on exercise metabolism. <\/span><i><span style=\"font-weight: 400;\">Current opinion in clinical nutrition and metabolic care. <\/span><\/i><span style=\"font-weight: 400;\">Jan 2007;10(1):46-51.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ranchordas MK WT. Effect of acute L-arginine supplementation on 20 km time trial performance in competitive male cyclists. <\/span><i><span style=\"font-weight: 400;\">British journal of sports medicine. <\/span><\/i><span style=\"font-weight: 400;\">2011;45:A11.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lomonosova YN, Shenkman BS, Kalamkarov GR, Kostrominova TY, Nemirovskaya TL. L-arginine supplementation protects exercise performance and structural integrity of muscle fibers after a single bout of eccentric exercise in rats. <\/span><i><span style=\"font-weight: 400;\">PloS one. <\/span><\/i><span style=\"font-weight: 400;\">2014;9(4):e94448.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Huang CC, Tsai SC, Lin WT. Potential ergogenic effects of L-arginine against oxidative and inflammatory stress induced by acute exercise in aging rats. <\/span><i><span style=\"font-weight: 400;\">Exp Gerontol. <\/span><\/i><span style=\"font-weight: 400;\">Jun 2008;43(6):571-577.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Boozer CN, Nasser JA, Heymsfield SB, Wang V, Chen G, Solomon JL. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. <\/span><i><span style=\"font-weight: 400;\">International journal of obesity and related metabolic disorders: journal of the International Association for the Study of Obesity. <\/span><\/i><span style=\"font-weight: 400;\">Mar 2001;25(3):316-324.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Burns J, Yokota T, Ashihara H, Lean ME, Crozier A. Plant foods and herbal sources of resveratrol. <\/span><i><span style=\"font-weight: 400;\">Journal of agricultural and food chemistry. <\/span><\/i><span style=\"font-weight: 400;\">May 22 2002;50(11):3337-3340.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Polley KR, Jenkins N, O&#8217;Connor P, McCully K. Influence of exercise training with resveratrol supplementation on skeletal muscle mitochondrial capacity. <\/span><i><span style=\"font-weight: 400;\">Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. <\/span><\/i><span style=\"font-weight: 400;\">Jan 2016;41(1):26-32.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Mohammadi Sartang M, Mazloom Z, Sohrabi Z, Sherafatmanesh S, Boldaji RB. Resveratrol supplementation and plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials. <\/span><i><span style=\"font-weight: 400;\">Pharmacological research: the official journal of the Italian Pharmacological Society. <\/span><\/i><span style=\"font-weight: 400;\">Jan 13 2017.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Diaz M, Degens H, Vanhees L, Austin C, Azzawi M. The effects of resveratrol on aging vessels. <\/span><i><span style=\"font-weight: 400;\">Exp Gerontol. <\/span><\/i><span style=\"font-weight: 400;\">Dec 01 2016;85:41-47.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Oyenihi OR, Oyenihi AB, Adeyanju AA, Oguntibeju OO. Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility. <\/span><i><span style=\"font-weight: 400;\">Journal of Diabetes Research. <\/span><\/i><span style=\"font-weight: 400;\">2016;2016:9737483.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Chen S, Zhao X, Ran L, Wan J, Wang X, Qin Y, . . . Mi M. Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: a randomized controlled trial. <\/span><i><span style=\"font-weight: 400;\">Dig Liver Dis. <\/span><\/i><span style=\"font-weight: 400;\">Mar 2015;47(3):226-232.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Menzies KJ, Singh K, Saleem A, Hood DA. Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis. <\/span><i><span style=\"font-weight: 400;\">The Journal of biological chemistry. <\/span><\/i><span style=\"font-weight: 400;\">Mar 8 2013;288(10):6968-6979.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Wu RE, Huang WC, Liao CC, Chang YK, Kan NW, Huang CC. Resveratrol protects against physical fatigue and improves exercise performance in mice. <\/span><i><span style=\"font-weight: 400;\">Molecules. <\/span><\/i><span style=\"font-weight: 400;\">2013;18(4):4689-4702.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dolinsky VW, Jones KE, Sidhu RS, Haykowsky M, Czubryt MP, Gordon T, Dyck JR. Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats. <\/span><i><span style=\"font-weight: 400;\">The Journal of physiology. <\/span><\/i><span style=\"font-weight: 400;\">Jun 1 2012;590(11):2783-2799.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lin-Na S, Yong-Xiu S. Effects of polysaccharides from Gynostemma pentaphyllum (Thunb.), Makino on physical fatigue. <\/span><i><span style=\"font-weight: 400;\">African journal of traditional, complementary, and alternative medicines: AJTCAM \/ African Networks on Ethnomedicines. <\/span><\/i><span style=\"font-weight: 400;\">2014;11(3):112-117.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nguyen PH, Gauhar R, Hwang SL, Dao TT, Park DC, Kim JE, . . . Oh WK. New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum. <\/span><i><span style=\"font-weight: 400;\">Bioorganic &amp; medicinal chemistry. <\/span><\/i><span style=\"font-weight: 400;\">Nov 1 2011;19(21):6254-6260.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Chi A, Tang L, Zhang J, Zhang K. Chemical composition of three polysaccharides from Gynostemma pentaphyllum and their antioxidant activity in skeletal muscle of exercised mice. <\/span><i><span style=\"font-weight: 400;\">International journal of sport nutrition and exercise metabolism. <\/span><\/i><span style=\"font-weight: 400;\">Dec 2012;22(6):479-485.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Chen S, Li Z, Krochmal R, Abrazado M, Kim W, Cooper CB. Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial. <\/span><i><span style=\"font-weight: 400;\">Journal of alternative and complementary medicine (New York, N.Y.). <\/span><\/i><span style=\"font-weight: 400;\">May 2010;16(5):585-590.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Chen CY, Hou CW, Bernard JR, Chen CC, Hung TC, Cheng LL, . . . Kuo CH. Rhodiola crenulata- and Cordyceps sinensis-based supplement boosts aerobic exercise performance after short-term high altitude training. <\/span><i><span style=\"font-weight: 400;\">High altitude medicine &amp; biology. <\/span><\/i><span style=\"font-weight: 400;\">Sep 2014;15(3):371-379.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Panda AK, Swain KC. Traditional uses and medicinal potential of Cordyceps sinensis of Sikkim. <\/span><i><span style=\"font-weight: 400;\">Journal of Ayurveda and integrative medicine. <\/span><\/i><span style=\"font-weight: 400;\">Jan 2011;2(1):9-13.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Kumar R, Negi PS, Singh B, Ilavazhagan G, Bhargava K, Sethy NK. Cordyceps sinensis promotes exercise endurance capacity of rats by activating skeletal muscle metabolic regulators. <\/span><i><span style=\"font-weight: 400;\">Journal of ethnopharmacology. <\/span><\/i><span style=\"font-weight: 400;\">Jun 14 2011;136(1):260-266.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Wang J, Li S, Fan Y, Chen Y, Liu D, Cheng H, . . . Zhou Y. Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C. A. Meyer. <\/span><i><span style=\"font-weight: 400;\">Journal of ethnopharmacology. <\/span><\/i><span style=\"font-weight: 400;\">Jul 20 2010;130(2):421-423.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Oliynyk S, Oh S. Actoprotective effect of ginseng: improving mental and physical performance. <\/span><i><span style=\"font-weight: 400;\">Journal of ginseng research. <\/span><\/i><span style=\"font-weight: 400;\">Apr 2013;37(2):144-166.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Chen CK, Muhamad AS, Ooi FK. Herbs in exercise and sports. <\/span><i><span style=\"font-weight: 400;\">Journal of physiological anthropology. <\/span><\/i><span style=\"font-weight: 400;\">2012;31:4.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Bucci LR. Selected herbals and human exercise performance. <\/span><i><span style=\"font-weight: 400;\">The American journal of clinical nutrition. <\/span><\/i><span style=\"font-weight: 400;\">Aug 2000;72(2 Suppl):624s-636s.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Wang LC, Lee TF. Effect of ginseng saponins on exercise performance in non-trained rats. <\/span><i><span style=\"font-weight: 400;\">Planta medica. <\/span><\/i><span style=\"font-weight: 400;\">Mar 1998;64(2):130-133.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Zhao W, Zhang X, Wang W, Zhang L. [Experimental study for the anti-fatigue effect of ginseng general ginsenosides P.E. in vivo]. <\/span><i><span style=\"font-weight: 400;\">Wei sheng yan jiu = Journal of hygiene research. <\/span><\/i><span style=\"font-weight: 400;\">Mar 2009;38(2):184-187.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nocerino E, Amato M, Izzo AA. The aphrodisiac and adaptogenic properties of ginseng. <\/span><i><span style=\"font-weight: 400;\">Fitoterapia. <\/span><\/i><span style=\"font-weight: 400;\">Aug 2000;71 Suppl 1:S1-5.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Kim SH, Park KS, Chang MJ, Sung JH. Effects of Panax ginseng extract on exercise-induced oxidative stress. <\/span><i><span style=\"font-weight: 400;\">The Journal of sports medicine and physical fitness. <\/span><\/i><span style=\"font-weight: 400;\">Jun 2005;45(2):178-182.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Liang MT, Podolka TD, Chuang WJ. Panax notoginseng supplementation enhances physical performance during endurance exercise. <\/span><i><span style=\"font-weight: 400;\">Journal of strength and conditioning research \/ National Strength &amp; Conditioning Association. <\/span><\/i><span style=\"font-weight: 400;\">Feb 2005;19(1):108-114.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Jung K, Kim IH, Han D. Effect of medicinal plant extracts on forced swimming capacity in mice. <\/span><i><span style=\"font-weight: 400;\">Journal of ethnopharmacology. <\/span><\/i><span style=\"font-weight: 400;\">Jul 2004;93(1):75-81.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Jia L, Zhao Y, Liang XJ. Current evaluation of the millennium phytomedicine- ginseng (II): Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine. <\/span><i><span style=\"font-weight: 400;\">Current medicinal chemistry. <\/span><\/i><span style=\"font-weight: 400;\">2009;16(22):2924-2942.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Kim KA, Yoo HH, Gu W, Yu DH, Jin MJ, Choi HL, . . . Kim DH. A prebiotic fiber increases the formation and subsequent absorption of compound K following oral administration of ginseng in rats. <\/span><i><span style=\"font-weight: 400;\">Journal of ginseng research. <\/span><\/i><span style=\"font-weight: 400;\">Apr 2015;39(2):183-187.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Bae EA, Choo MK, Park EK, Park SY, Shin HY, Kim DH. Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity. <\/span><i><span style=\"font-weight: 400;\">Biological &amp; pharmaceutical bulletin. <\/span><\/i><span style=\"font-weight: 400;\">Jun 2002;25(6):743-747.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Jin H, Seo JH, Uhm YK, Jung CY, Lee SK, Yim SV. Pharmacokinetic comparison of ginsenoside metabolite IH-901 from fermented and non-fermented ginseng in healthy Korean volunteers. <\/span><i><span style=\"font-weight: 400;\">Journal of ethnopharmacology. <\/span><\/i><span style=\"font-weight: 400;\">Jan 31 2012;139(2):664-667.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Hasegawa H. Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid. <\/span><i><span style=\"font-weight: 400;\">Journal of pharmacological sciences. <\/span><\/i><span style=\"font-weight: 400;\">Jun 2004;95(2):153-157.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Noreen EE, Buckley JG, Lewis SL, Brandauer J, Stuempfle KJ. The effects of an acute dose of Rhodiola rosea on endurance exercise performance. <\/span><i><span style=\"font-weight: 400;\">Journal of strength and conditioning research \/ National Strength &amp; Conditioning Association. <\/span><\/i><span style=\"font-weight: 400;\">Mar 2013;27(3):839-847.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Duncan MJ, Clarke ND. The Effect of Acute Rhodiola rosea Ingestion on Exercise Heart Rate, Substrate Utilisation, Mood State, and Perceptions of Exertion, Arousal, and Pleasure\/Displeasure in Active Men. <\/span><i><span style=\"font-weight: 400;\">Journal of sports medicine (Hindawi Publishing Corporation). <\/span><\/i><span style=\"font-weight: 400;\">2014;2014:563043.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lee FT, Kuo TY, Liou SY, Chien CT. Chronic Rhodiola rosea extract supplementation enforces exhaustive swimming tolerance. <\/span><i><span style=\"font-weight: 400;\">The American journal of Chinese medicine. <\/span><\/i><span style=\"font-weight: 400;\">2009;37(3):557-572.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">De Bock K, Eijnde BO, Ramaekers M, Hespel P. Acute Rhodiola rosea intake can improve endurance exercise performance. <\/span><i><span style=\"font-weight: 400;\">International journal of sport nutrition and exercise metabolism. <\/span><\/i><span style=\"font-weight: 400;\">Jun 2004;14(3):298-307.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Parisi A, Tranchita E, Duranti G, Ciminelli E, Quaranta F, Ceci R, . . . Sabatini S. Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results. <\/span><i><span style=\"font-weight: 400;\">The Journal of sports medicine and physical fitness. <\/span><\/i><span style=\"font-weight: 400;\">Mar 2010;50(1):57-63.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Walker TB, Robergs RA. Does Rhodiola rosea possess ergogenic properties? <\/span><i><span style=\"font-weight: 400;\">International journal of sport nutrition and exercise metabolism. <\/span><\/i><span style=\"font-weight: 400;\">Jun 2006;16(3):305-315.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Slater GJ, Jenkins D. Beta-hydroxy-beta-methylbutyrate (HMB) supplementation and the promotion of muscle growth and strength. <\/span><i><span style=\"font-weight: 400;\">Sports medicine (Auckland, NZ). <\/span><\/i><span style=\"font-weight: 400;\">2000;30(2):105-116.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Rittig N, Bach E, Thomsen HH, et al. Anabolic effects of leucine-rich whey protein, carbohydrate, and soy protein with and without beta-hydroxy-beta-methylbutyrate (HMB) during fasting-induced catabolism: A human randomized crossover trial. <\/span><i><span style=\"font-weight: 400;\">Clin Nutr. <\/span><\/i><span style=\"font-weight: 400;\">2017;36(3):697-705.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Asadi A, Arazi H, Suzuki K. Effects of beta-Hydroxy-beta-methylbutyrate-free Acid Supplementation on Strength, Power and Hormonal Adaptations Following Resistance Training. <\/span><i><span style=\"font-weight: 400;\">Nutrients. <\/span><\/i><span style=\"font-weight: 400;\">2017;9(12).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Zanchi NE, Gerlinger-Romero F, Guimaraes-Ferreira L, et al. HMB supplementation: clinical and athletic performance-related effects and mechanisms of action. <\/span><i><span style=\"font-weight: 400;\">Amino Acids. <\/span><\/i><span style=\"font-weight: 400;\">2011;40(4):1015-1025.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Deutz NE, Pereira SL, Hays NP, et al. Effect of beta-hydroxy-beta-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults. <\/span><i><span style=\"font-weight: 400;\">Clin Nutr. <\/span><\/i><span style=\"font-weight: 400;\">2013;32(5):704-712.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Knitter AE, Panton L, Rathmacher JA, Petersen A, Sharp R. Effects of \u03b2-hydroxy-\u03b2-methylbutyrate on muscle damage after a prolonged run. <\/span><i><span style=\"font-weight: 400;\">Journal of Applied Physiology. <\/span><\/i><span style=\"font-weight: 400;\">2000;89(4):1340-1344.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Stout JR, Smith-Ryan AE, Fukuda DH, et al. Effect of calcium \u03b2-hydroxy-\u03b2-methylbutyrate (CaHMB) with and without resistance training in men and women 65+yrs: A randomized, double-blind pilot trial. <\/span><i><span style=\"font-weight: 400;\">Experimental Gerontology. <\/span><\/i><span style=\"font-weight: 400;\">2013;48(11):1303-1310.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Wilson JM, Lowery RP, Joy JM, et al. \u03b2-Hydroxy-\u03b2-methylbutyrate free acid reduces markers of exercise-induced muscle damage and improves recovery in resistance-trained men. <\/span><i><span style=\"font-weight: 400;\">British Journal of Nutrition. <\/span><\/i><span style=\"font-weight: 400;\">2013;110(3):538-544.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Rowlands DS, Thomson JS. Effects of \u03b2-Hydroxy-\u03b2-Methylbutyrate Supplementation During Resistance Training on Strength, Body Composition, and Muscle Damage in Trained and Untrained Young Men: A Meta-Analysis. <\/span><i><span style=\"font-weight: 400;\">The Journal of Strength &amp; Conditioning Research. <\/span><\/i><span style=\"font-weight: 400;\">2009;23(3):836-846.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Horowitz AM, Fan X, Bieri G, et al. Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain. <\/span><i><span style=\"font-weight: 400;\">Science (New York, NY)<\/span><\/i><span style=\"font-weight: 400;\">. 2020;369(6500):167-173.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Panfoli I, Puddu A, Bertola N, Ravera S, Maggi D. The Hormetic Effect of Metformin: &#8220;Less Is More&#8221;? International journal of molecular sciences. Jun 11 2021;22(12)doi:10.3390\/ijms22126297.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Malin SK, Stewart NR. Metformin May Contribute to Inter-individual Variability for Glycemic Responses to Exercise. Frontiers in endocrinology. 2020;11:519. doi:10.3389\/fendo.2020.00519.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Kaneto H, Kimura T, Obata A, Shimoda M, Kaku K. Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History. International journal of molecular sciences. Mar 5 2021;22(5)doi:10.3390\/ijms22052596.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ortega JF, Hamouti N, Fern\u00e1ndez-El\u00edas VE, de Prada MV, Mart\u00ednez-Vizca\u00edno V, Mora-Rodr\u00edguez R. Metformin does not attenuate the acute insulin-sensitizing effect of a single bout of exercise in individuals with insulin resistance. Acta Diabetol. Oct 2014;51(5):749-55. doi:10.1007\/s00592-014-0580-4.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Huang T, Lu C, Schumann M, et al. Timing of Exercise Affects Glycemic Control in Type 2 Diabetes Patients Treated with Metformin. J Diabetes Res. 2018;2018:2483273. doi:10.1155\/2018\/2483273.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Erickson ML, Little JP, Gay JL, McCully KK, Jenkins NT. Postmeal exercise blunts postprandial glucose excursions in people on metformin monotherapy. J Appl Physiol (1985). Aug 1 2017;123(2):444-450. doi:10.1152\/japplphysiol.00213.2017.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Boul\u00e9 NG, Robert C, Bell GJ, et al. Metformin and exercise in type 2 diabetes: examining treatment modality interactions. Diabetes Care. Jul 2011;34(7):1469-74. doi:10.2337\/dc10-2207.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Myette-C\u00f4t\u00e9 \u00c9, Terada T, Boul\u00e9 NG. The Effect of Exercise with or Without Metformin on Glucose Profiles in Type 2 Diabetes: A Pilot Study. Canadian journal of diabetes. Apr 2016;40(2):173-7. doi:10.1016\/j.jcjd.2015.08.015.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Boul\u00e9 NG, Kenny GP, Larose J, Khandwala F, Kuzik N, Sigal RJ. Does metformin modify the effect on glycaemic control of aerobic exercise, resistance exercise or both? Diabetologia. Nov 2013;56(11):2378-82. doi:10.1007\/s00125-013-3026-6.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Terada T, Boul\u00e9 NG. Does metformin therapy influence the effects of intensive lifestyle intervention? Exploring the interaction between first line therapies in the Look AHEAD trial. Metabolism: clinical and experimental. May 2019;94:39-46. doi:10.1016\/j.metabol.2019.01.004<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Konopka AR, Laurin JL, Schoenberg HM, et al. Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. Aging Cell. Feb 2019;18(1):e12880. doi:10.1111\/acel.12880.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Malin SK, Gerber R, Chipkin SR, Braun B. Independent and combined effects of exercise training and metformin on insulin sensitivity in individuals with prediabetes. Diabetes Care. Jan 2012;35(1):131-6. doi:10.2337\/dc11-0925.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Malin SK, Nightingale J, Choi SE, Chipkin SR, Braun B. Metformin modifies the exercise training effects on risk factors for cardiovascular disease in impaired glucose tolerant adults. Obesity (Silver Spring). Jan 2013;21(1):93-100. doi:10.1002\/oby.20235.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Walton RG, Dungan CM, Long DE, et al. Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double-blind, placebo-controlled, multicenter trial: The MASTERS trial. Aging Cell. Dec 2019;18(6):e13039. doi:10.1111\/acel.13039.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Kristensen JM, Lillelund C, Kj\u00f8bsted R, et al. Metformin does not compromise energy status in human skeletal muscle at rest or during acute exercise: A randomised, crossover trial. Physiological reports. Dec 2019;7(23):e14307. doi:10.14814\/phy2.14307.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Pilmark NS, Petersen-B\u00f8nding C, Holm NFR, et al. The Effect of Metformin on Self-Selected Exercise Intensity in Healthy, Lean Males: A Randomized, Crossover, Counterbalanced Trial. Frontiers in endocrinology. 2021;12:599164. doi:10.3389\/fendo.2021.599164.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Radak Z, Ishihara K, Tekus E, et al. Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve. Redox biology. Aug 2017;12:285-290. doi:10.1016\/j.redox.2017.02.015.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Perim P, Marticorena FM, Ribeiro F, et al. Can the Skeletal Muscle Carnosine Response to Beta-Alanine Supplementation Be Optimized? <\/span><i><span style=\"font-weight: 400;\">Frontiers in nutrition<\/span><\/i><span style=\"font-weight: 400;\">. 2019;6:135. doi:10.3389\/fnut.2019.00135<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Budzen S, Rymaszewska J. The biological role of carnosine and its possible applications in medicine. <\/span><i><span style=\"font-weight: 400;\">Adv Clin Exp Med<\/span><\/i><span style=\"font-weight: 400;\">. Sep-Oct 2013;22(5):739-44.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Matthews JJ, Artioli GG, Turner MD, Sale C. The Physiological Roles of Carnosine and beta-Alanine in Exercising Human Skeletal Muscle. <\/span><i><span style=\"font-weight: 400;\">Medicine and science in sports and exercise<\/span><\/i><span style=\"font-weight: 400;\">. Oct 2019;51(10):2098-2108. doi:10.1249\/MSS.0000000000002033<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Hobson RM, Saunders B, Ball G, Harris RC, Sale C. Effects of beta-alanine supplementation on exercise performance: a meta-analysis. <\/span><i><span style=\"font-weight: 400;\">Amino Acids<\/span><\/i><span style=\"font-weight: 400;\">. Jul 2012;43(1):25-37. doi:10.1007\/s00726-011-1200-z<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>O que todos n\u00f3s procuramos \u00e9 melhorar nossa performance nas atividades em que exercemos para alcan\u00e7armos de forma mais r\u00e1pida e eficiente os objetivos esperados. O exerc\u00edcio f\u00edsico com uma alimenta\u00e7\u00e3o e nutri\u00e7\u00e3o adequada s\u00e3o essenciais para a conquista dos resultados. A suplementa\u00e7\u00e3o com ativos que s\u00e3o capazes de melhorar a execu\u00e7\u00e3o dessas atividades e [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":599,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[177,115,116,175,167,176],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Estrat\u00e9gias para melhorar a performance - Evidence - Ci\u00eancia e Pesquisa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/estrategias-para-melhorar-a-performance-2\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Estrat\u00e9gias para melhorar a performance - Evidence - Ci\u00eancia e Pesquisa\" \/>\n<meta property=\"og:description\" content=\"O que todos n\u00f3s procuramos \u00e9 melhorar nossa performance nas atividades em que exercemos para alcan\u00e7armos de forma mais r\u00e1pida e eficiente os objetivos esperados. O exerc\u00edcio f\u00edsico com uma alimenta\u00e7\u00e3o e nutri\u00e7\u00e3o adequada s\u00e3o essenciais para a conquista dos resultados. A suplementa\u00e7\u00e3o com ativos que s\u00e3o capazes de melhorar a execu\u00e7\u00e3o dessas atividades e [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/estrategias-para-melhorar-a-performance-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Evidence - Ci\u00eancia e Pesquisa\" \/>\n<meta property=\"article:published_time\" content=\"2022-06-28T17:46:28+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/wp-content\/uploads\/sites\/2\/2022\/06\/melhora-da-performance.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"665\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. tempo de leitura\">\n\t<meta name=\"twitter:data1\" content=\"17 minutos\">\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/#website\",\"url\":\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/\",\"name\":\"Evidence - Ci\\u00eancia e Pesquisa\",\"description\":\"S\\u00f3 mais um site Evidence\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/?s={search_term_string}\",\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"pt-BR\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/estrategias-para-melhorar-a-performance-2\/#primaryimage\",\"inLanguage\":\"pt-BR\",\"url\":\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/wp-content\/uploads\/sites\/2\/2022\/06\/melhora-da-performance.jpg\",\"width\":1000,\"height\":665},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/estrategias-para-melhorar-a-performance-2\/#webpage\",\"url\":\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/estrategias-para-melhorar-a-performance-2\/\",\"name\":\"Estrat\\u00e9gias para melhorar a performance - Evidence - Ci\\u00eancia e Pesquisa\",\"isPartOf\":{\"@id\":\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/estrategias-para-melhorar-a-performance-2\/#primaryimage\"},\"datePublished\":\"2022-06-28T17:46:28+00:00\",\"dateModified\":\"2022-06-28T17:46:28+00:00\",\"author\":{\"@id\":\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/#\/schema\/person\/88900ffe7397a6daa8bfd75eed685d05\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/estrategias-para-melhorar-a-performance-2\/#breadcrumb\"},\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/estrategias-para-melhorar-a-performance-2\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/estrategias-para-melhorar-a-performance-2\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/estrategias-para-melhorar-a-performance-2\/\",\"url\":\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/estrategias-para-melhorar-a-performance-2\/\",\"name\":\"Estrat\\u00e9gias para melhorar a performance\"}}]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/#\/schema\/person\/88900ffe7397a6daa8bfd75eed685d05\",\"name\":\"felipe\",\"image\":{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/#personlogo\",\"inLanguage\":\"pt-BR\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/4b00cbf273517f54210d03c0b311d228?s=96&d=mm&r=g\",\"caption\":\"felipe\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","_links":{"self":[{"href":"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/wp-json\/wp\/v2\/posts\/620"}],"collection":[{"href":"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/wp-json\/wp\/v2\/comments?post=620"}],"version-history":[{"count":1,"href":"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/wp-json\/wp\/v2\/posts\/620\/revisions"}],"predecessor-version":[{"id":621,"href":"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/wp-json\/wp\/v2\/posts\/620\/revisions\/621"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/wp-json\/wp\/v2\/media\/599"}],"wp:attachment":[{"href":"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/wp-json\/wp\/v2\/media?parent=620"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/wp-json\/wp\/v2\/categories?post=620"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/wp-json\/wp\/v2\/tags?post=620"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}