{"id":502,"date":"2022-01-07T12:52:38","date_gmt":"2022-01-07T15:52:38","guid":{"rendered":"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/?p=502"},"modified":"2022-01-11T09:54:20","modified_gmt":"2022-01-11T12:54:20","slug":"smart-drugs-ii-luteina-e-zeaxantina","status":"publish","type":"post","link":"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/smart-drugs-ii-luteina-e-zeaxantina\/","title":{"rendered":"Smart Drugs II &#8211; Lute\u00edna e Zeaxantina"},"content":{"rendered":"<p>Lute\u00edna e Zeaxantina<\/p>\n<p><span style=\"font-weight: 400;\">Nootr\u00f3picos s\u00e3o compostos que podem melhorar o desempenho cognitivo em adultos saud\u00e1veis. Os ensaios cl\u00ednicos mostram que os caroten\u00f3ides lute\u00edna e zeaxantina podem melhorar com seguran\u00e7a a mem\u00f3ria, o aprendizado, a concentra\u00e7\u00e3o e a velocidade de processamento da informa\u00e7\u00e3o.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Esses compostos reduzem o dano oxidativo e a inflama\u00e7\u00e3o no c\u00e9rebro e melhoram a comunica\u00e7\u00e3o entre as c\u00e9lulas cerebrais.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Caroten\u00f3ides e a conex\u00e3o c\u00e9rebro-olho<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Os caroten\u00f3ides s\u00e3o um grupo de pigmentos encontrados em muitas frutas e vegetais. A lute\u00edna e a zeaxantina s\u00e3o caroten\u00f3ides intimamente relacionados que desempenham um papel vital na manuten\u00e7\u00e3o de uma vis\u00e3o saud\u00e1vel. Eles ajudam a proteger a densidade macular necess\u00e1ria para a fun\u00e7\u00e3o visual.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A maior parte da lute\u00edna e zeaxantina obtidas na dieta \u00e9 absorvida pela retina, a camada mais interna do olho, e concentrada em uma regi\u00e3o pr\u00f3xima ao centro da retina conhecida como m\u00e1cula.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A retina \u00e9 composta por c\u00e9lulas nervosas e \u00e9 uma extens\u00e3o do c\u00e9rebro. Os pesquisadores descobriram que a lute\u00edna e a zeaxantina tamb\u00e9m se acumulam no c\u00e9rebro e desempenham um papel importante na fun\u00e7\u00e3o cognitiva. Os cientistas s\u00e3o capazes de medir facilmente os n\u00edveis de lute\u00edna e zeaxantina na m\u00e1cula e descobriram que elas se correlacionam com os n\u00edveis no c\u00e9rebro.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Eles tamb\u00e9m determinaram que os n\u00edveis de lute\u00edna e zeaxantina na m\u00e1cula e no soro sangu\u00edneo est\u00e3o associados \u00e0 fun\u00e7\u00e3o cognitiva. Por exemplo, indiv\u00edduos com comprometimento cognitivo leve ou doen\u00e7a de Alzheimer t\u00eam n\u00edveis mais baixos desses pigmentos caroten\u00f3ides na m\u00e1cula ou no soro sangu\u00edneo.<\/span><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lute\u00edna e zeaxantina melhoram o desempenho mental<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Numerosos ensaios cl\u00ednicos exploraram os efeitos da ingest\u00e3o de lute\u00edna e zeaxantina no desempenho cognitivo em adultos jovens e idosos saud\u00e1veis. Esses estudos em humanos mostram que a ingest\u00e3o de lute\u00edna e zeaxantina pode melhorar:<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Velocidade de processamento da informa\u00e7\u00e3o;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Habilidade de racioc\u00ednio;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mem\u00f3ria;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rea\u00e7\u00e3o visual motora;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aten\u00e7\u00e3o;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Desempenho verbal e visual;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Flexibilidade cognitiva, a capacidade de mudar as estrat\u00e9gias mentais de acordo com a tarefa.\u00a0<\/span><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">Uma revis\u00e3o de estudos anteriores publicados em 2020 descobriu que a lute\u00edna e a zeaxantina foram consistentemente eficazes em melhorar a aten\u00e7\u00e3o e a lembran\u00e7a de eventos, situa\u00e7\u00f5es e experi\u00eancias a longo prazo (<\/span><span style=\"font-weight: 400;\">Nouchi<\/span><i><span style=\"font-weight: 400;\"> et al<\/span><\/i><span style=\"font-weight: 400;\">., 2020).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Usando a varredura do c\u00e9rebro, os cientistas descobriram que os n\u00edveis de lute\u00edna e zeaxantina no soro e na m\u00e1cula est\u00e3o associados ao aumento da integridade da subst\u00e2ncia branca (que consiste em fibras nervosas que conectam as c\u00e9lulas cerebrais) em indiv\u00edduos mais velhos (<\/span><span style=\"font-weight: 400;\">Mewborn <\/span><i><span style=\"font-weight: 400;\">et al<\/span><\/i><span style=\"font-weight: 400;\">., 2018).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Os caroten\u00f3ides tamb\u00e9m podem aumentar a express\u00e3o de prote\u00ednas que formam as jun\u00e7\u00f5es comunicantes (<\/span><span style=\"font-weight: 400;\">Hix, Lockwood &amp; Bertram, 2004).<\/span><span style=\"font-weight: 400;\"> As jun\u00e7\u00f5es de lacuna s\u00e3o canais que permitem que c\u00e9lulas vizinhas se comuniquem diretamente umas com as outras. <\/span><i><span style=\"font-weight: 400;\">O <\/span><\/i><span style=\"font-weight: 400;\">aumento da comunica\u00e7\u00e3o de jun\u00e7\u00f5es de lacuna pode melhorar o desempenho cognitivo (<\/span><span style=\"font-weight: 400;\">Johnson, 2014).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A lute\u00edna e a zeaxantina parecem aumentar a coopera\u00e7\u00e3o entre regi\u00f5es cerebrais que anteriormente funcionavam de forma isolada, para aumentar o fluxo sangu\u00edneo para o c\u00e9rebro e para combater o dano oxidativo no c\u00e9rebro (<\/span><span style=\"font-weight: 400;\">Lindbergh <\/span><i><span style=\"font-weight: 400;\">et al.<\/span><\/i><span style=\"font-weight: 400;\">, 2018; Lindbergh <\/span><i><span style=\"font-weight: 400;\">et al<\/span><\/i><span style=\"font-weight: 400;\">., 2020; Sindhu, Preethi &amp; Kuttan<\/span><span style=\"font-weight: 400;\">, 2010; <\/span><span style=\"font-weight: 400;\">Madhavan<\/span><i><span style=\"font-weight: 400;\"> et al<\/span><\/i><span style=\"font-weight: 400;\">., 2018)<\/span><span style=\"font-weight: 400;\">. Todas essas a\u00e7\u00f5es podem ajudar a melhorar o desempenho cognitivo.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Combinar esses caroten\u00f3ides com <\/span><i><span style=\"font-weight: 400;\">Bacopa monnieri<\/span><\/i><span style=\"font-weight: 400;\"> e gotu kola pode ajudar a maximizar o potencial total do c\u00e9rebro.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">Refer\u00eancias<\/span><\/p>\n<p>&nbsp;<\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Life Extension. Dispon\u00edvel em &lt;https:\/\/www.lifeextension.com\/magazine\/2021\/12\/brain-speed-learning-retention&gt; Acesso: novembro, 2021.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bian Q, Gao S, Zhou J, et al. Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells. <\/span><i><span style=\"font-weight: 400;\">Free Radic Biol Med. <\/span><\/i><span style=\"font-weight: 400;\">2012 Sep 15;53(6):1298-307.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chucair AJ, Rotstein NP, Sangiovanni JP, et al. Lutein and zeaxanthin protect photoreceptors from apoptosis induced by oxidative stress: relation with docosahexaenoic acid. <\/span><i><span style=\"font-weight: 400;\">Invest Ophthalmol Vis Sci. <\/span><\/i><span style=\"font-weight: 400;\">2007 Nov;48(11):5168-77.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kijlstra A, Tian Y, Kelly ER, et al. Lutein: more than just a filter for blue light. <\/span><i><span style=\"font-weight: 400;\">Prog Retin Eye Res. <\/span><\/i><span style=\"font-weight: 400;\">2012 Jul;31(4):303-15.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loskutova E, Nolan J, Howard A, et al. Macular pigment and its contribution to vision. <\/span><i><span style=\"font-weight: 400;\">Nutrients. <\/span><\/i><span style=\"font-weight: 400;\">2013 May 29;5(6):1962-9.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Strauss O. The retinal pigment epithelium in visual function. <\/span><i><span style=\"font-weight: 400;\">Physiol Rev. <\/span><\/i><span style=\"font-weight: 400;\">2005 Jul;85(3):845-81.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Xue C, Rosen R, Jordan A, et al. Management of Ocular Diseases Using Lutein and Zeaxanthin: What Have We Learned from Experimental Animal Studies? <\/span><i><span style=\"font-weight: 400;\">J Ophthalmol. <\/span><\/i><span style=\"font-weight: 400;\">2015;2015:523027.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hix LM, Lockwood SF, Bertram JS. Bioactive carotenoids: potent antioxidants and regulators of gene expression. <\/span><i><span style=\"font-weight: 400;\">Redox Rep. <\/span><\/i><span style=\"font-weight: 400;\">2004;9(4):181-91.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Johnson EJ. Role of lutein and zeaxanthin in visual and cognitive function throughout the lifespan. <\/span><i><span style=\"font-weight: 400;\">Nutr Rev. <\/span><\/i><span style=\"font-weight: 400;\">2014 Sep;72(9):605-12.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vishwanathan R, Neuringer M, Snodderly DM, et al. Macular lutein and zeaxanthin are related to brain lutein and zeaxanthin in primates. <\/span><i><span style=\"font-weight: 400;\">Nutr Neurosci. <\/span><\/i><span style=\"font-weight: 400;\">2013 Jan;16(1):21-9.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Johnson EJ. A possible role for lutein and zeaxanthin in cognitive function in the elderly. <\/span><i><span style=\"font-weight: 400;\">Am J Clin Nutr. <\/span><\/i><span style=\"font-weight: 400;\">2012 Nov;96(5):1161S-5S.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Renzi LM, Dengler MJ, Puente A, et al. Relationships between macular pigment optical density and cognitive function in unimpaired and mildly cognitively impaired older adults. <\/span><i><span style=\"font-weight: 400;\">Neurobiology of aging.<\/span><\/i><span style=\"font-weight: 400;\"> 2014;35(7):1695-9.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vishwanathan R, Iannaccone A, Scott TM, et al. Macular pigment optical density is related to cognitive function in older people. <\/span><i><span style=\"font-weight: 400;\">Age and ageing. <\/span><\/i><span style=\"font-weight: 400;\">2014;43(2):271-5.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Walk AM, Edwards CG, Baumgartner NW, et al. The Role of Retinal Carotenoids and Age on Neuroelectric Indices of Attentional Control among Early to Middle-Aged Adults. <\/span><i><span style=\"font-weight: 400;\">Front Aging Neurosci. <\/span><\/i><span style=\"font-weight: 400;\">2017 2017-June-09;9(183):183.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Johnson EJ, Vishwanathan R, Johnson MA, et al. Relationship between Serum and Brain Carotenoids, alpha-Tocopherol, and Retinol Concentrations and Cognitive Performance in the Oldest Old from the Georgia Centenarian Study. <\/span><i><span style=\"font-weight: 400;\">J Aging Res. <\/span><\/i><span style=\"font-weight: 400;\">2013;2013:951786.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nolan JM, Loskutova E, Howard AN, et al. Macular pigment, visual function, and macular disease among subjects with Alzheimer\u2019s disease: an exploratory study. <\/span><i><span style=\"font-weight: 400;\">Journal of Alzheimer\u2019s disease. <\/span><\/i><span style=\"font-weight: 400;\">2014;42(4):1191-202.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bovier ER, Hammond BR. A randomized placebo-controlled study on the effects of lutein and zeaxanthin on visual processing speed in young healthy subjects. <\/span><i><span style=\"font-weight: 400;\">Arch Biochem Biophys. <\/span><\/i><span style=\"font-weight: 400;\">2015 Apr 15;572:54-7.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bovier ER, Renzi LM, Hammond BR. A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on neural processing speed and efficiency. <\/span><i><span style=\"font-weight: 400;\">PLoS One. <\/span><\/i><span style=\"font-weight: 400;\">2014;9(9):e108178.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Renzi-Hammond LM, Bovier ER, Fletcher LM, et al. Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults. <\/span><i><span style=\"font-weight: 400;\">Nutrients. <\/span><\/i><span style=\"font-weight: 400;\">2017 Nov 14;9(11).<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hammond Jr BR, Miller LS, Bello MO, et al. Effects of lutein\/zeaxanthin supplementation on the cognitive function of community dwelling older adults: a randomized, double-masked, placebo-controlled trial. <\/span><i><span style=\"font-weight: 400;\">Frontiers in aging neuroscience. <\/span><\/i><span style=\"font-weight: 400;\">2017;9:254.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Power R, Coen RF, Beatty S, et al. Supplemental Retinal Carotenoids Enhance Memory in Healthy Individuals with Low Levels of Macular Pigment in A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. <\/span><i><span style=\"font-weight: 400;\">J Alzheimers Dis. <\/span><\/i><span style=\"font-weight: 400;\">2018;61(3):947-61.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lindbergh CA, Renzi-Hammond LM, Hammond BR, et al. Lutein and Zeaxanthin Influence Brain Function in Older Adults: A Randomized Controlled Trial. <\/span><i><span style=\"font-weight: 400;\">J Int Neuropsychol Soc. <\/span><\/i><span style=\"font-weight: 400;\">2018 Jan;24(1):77-90.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nouchi R, Suiko T, Kimura E, et al. Effects of lutein and astaxanthin intake on the improvement of cognitive functions among healthy adults: a systematic review of randomized controlled trials. <\/span><i><span style=\"font-weight: 400;\">Nutrients.<\/span><\/i><span style=\"font-weight: 400;\"> 2020;12(3):617.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mewborn CM, Terry DP, Renzi-Hammond LM, et al. Relation of Retinal and Serum Lutein and Zeaxanthin to White Matter Integrity in Older Adults: A Diffusion Tensor Imaging Study. <\/span><i><span style=\"font-weight: 400;\">Arch Clin Neuropsychol. <\/span><\/i><span style=\"font-weight: 400;\">2018 Nov 1;33(7):861-74.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lindbergh CA, Lv J, Zhao Y, et al. The effects of lutein and zeaxanthin on resting state functional connectivity in older Caucasian adults: a randomized controlled trial. <\/span><i><span style=\"font-weight: 400;\">Brain Imaging Behav. <\/span><\/i><span style=\"font-weight: 400;\">2020 Jun;14(3):668-81.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sindhu ER, Preethi KC, Kuttan R. Antioxidant activity of carotenoid lutein in vitro and in vivo. <\/span><i><span style=\"font-weight: 400;\">Indian J Exp Biol. <\/span><\/i><span style=\"font-weight: 400;\">2010 Aug;48(8):843-8.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Madhavan J, Chandrasekharan S, Priya MK, et al. Modulatory Effect of Carotenoid Supplement Constituting Lutein and Zeaxanthin (10:1) on Anti-oxidant Enzymes and Macular Pigments Level in Rats. <\/span><i><span style=\"font-weight: 400;\">Pharmacogn Mag. <\/span><\/i><span style=\"font-weight: 400;\">2018 Apr-Jun;14(54):268-74.<\/span><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Lute\u00edna e Zeaxantina Nootr\u00f3picos s\u00e3o compostos que podem melhorar o desempenho cognitivo em adultos saud\u00e1veis. Os ensaios cl\u00ednicos mostram que os caroten\u00f3ides lute\u00edna e zeaxantina podem melhorar com seguran\u00e7a a mem\u00f3ria, o aprendizado, a concentra\u00e7\u00e3o e a velocidade de processamento da informa\u00e7\u00e3o. Esses compostos reduzem o dano oxidativo e a inflama\u00e7\u00e3o no c\u00e9rebro e melhoram [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":513,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[68,44,67,65,55,61,42,38,62,66],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Smart Drugs II - Lute\u00edna e Zeaxantina - Evidence - Ci\u00eancia e Pesquisa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.farmaciaevidence.com.br\/ciencia-pesquisa\/smart-drugs-ii-luteina-e-zeaxantina\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Smart Drugs II - Lute\u00edna e Zeaxantina - Evidence - Ci\u00eancia e Pesquisa\" \/>\n<meta property=\"og:description\" content=\"Lute\u00edna e Zeaxantina Nootr\u00f3picos s\u00e3o compostos que podem melhorar o desempenho cognitivo em adultos saud\u00e1veis. Os ensaios cl\u00ednicos mostram que os caroten\u00f3ides lute\u00edna e zeaxantina podem melhorar com seguran\u00e7a a mem\u00f3ria, o aprendizado, a concentra\u00e7\u00e3o e a velocidade de processamento da informa\u00e7\u00e3o. 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